重井医学研究所

研究業績Publication

分子遺伝部門  Division of Molecular Genetics

Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.
Yamakawa D, Katoh D, Kasahara K, Shiromizu T, Matsuyama M, Matsuda C, Maeno Y, Watanabe M, Nishimura Y, Inagaki M.
Cell Rep. 2021 Mar 9;34(10):108817. doi: 10.1016/j.celrep.2021.108817.
PubMed

 

Majority of alpha2,6-sialylated glycans in adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
Ohmi Y, Nishikaze T, Kitaura Y, Ito T, Yamamoto S, Sugiyama F, Matsuyama M, Takahashi Y, Takeda A, Kawahara T, Okajima T, Furukawa K, Furukawa K.
Glycobiology. 2020 Nov 25:cwaa105. doi: 10.1093/glycob/cwaa105.
PubMed

 

Antiproliferative Effects of Monoclonal Antibodies against (Pro)Renin Receptor in Pancreatic Ductal Adenocarcinoma.
Rahman A, Matsuyama M, Ebihara A, Shibayama Y, Hasan AU, Nakagami H, Suzuki F, Sun J, Kobayashi T, Hayashi H, Nakano D, Kobara H, Masaki T, Nishiyama A.
Mol Cancer Ther. 2020 Sep;19(9):1844-1855. doi: 10.1158/1535-7163.MCT-19-0228. Epub 2020 Jul 15.
PubMed

 

Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†.
Nozawa K, Zhang Q, Miyata H, Devlin DJ, Yu Z, Oura S, Koyano T, Matsuyama M, Ikawa M, Matzuk MM.
Biol Reprod. 2020 Aug 4;103(2):244-253. doi: 10.1093/biolre/ioaa040.
PubMed

 

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.
Noda T, Lu Y, Fujihara Y, Oura S, Koyano T, Kobayashi S, Matzuk MM, Ikawa M.
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502. doi: 10.1073/pnas.1922650117. Epub 2020 May 11.
PubMed

 

The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers.
Wang J, Nishiyama A, Matsuyama M, Wang Z, Yuan Y.
Cell Commun Signal. 2020 Mar 6;18(1):39. doi: 10.1186/s12964-020-0531-3.
PubMed

 

The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
Kumrungsee T, Kariya T, Hashimoto K, Koyano T, Yazawa N, Hashimoto T, Sanada Y, Matsuyama M, Sotomaru Y, Sakurai H, van de Loo FAJ, Yanaka N.
Sci Rep. 2019 Oct 1;9(1):14101. doi: 10.1038/s41598-019-50685-0.
PubMed

 

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis.
Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Takahashi M, Enomoto A.
Cancer Res. 2019 Aug 22. pii: canres.0454.2019. doi: 10.1158/0008-5472.
PubMed

 

The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis.
Koyano T, Namba M, Kobayashi T, Nakakuni K, Nakano D, Fukushima M, Nishiyama A, Matsuyama M.
Sci Rep. 2019 Aug 19;9(1):12059. doi: 10.1038/s41598-019-48557-8.
PubMed

 

Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD.
Gurumurthy CB, Sato M, Nakamura A, Inui M, Kawano N, Islam MA, Ogiwara S, Takabayashi S, Matsuyama M, Nakagawa S, Miura H, Ohtsuka M.
Nat Protoc. 2019 Aug;14(8):2452-2482. doi: 10.1038/s41596-019-0187-x.
PubMed

 

Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain.
Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, Ihara Y, Misonou H, Miyasaka T.
J Neurosci. 2019 Aug 21;39(34):6781-6797.doi:10.1523/JNEUROSCI.2845-18.2019. Epub 2019 Jun 24.
PubMed

 

Distribution of endogenous normal tau in the mouse brain.
Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T.
J Comp Neurol. 2019 Apr 1;527(5):985-998. doi: 10.1002/cne.24577.
PubMed

 

Successful production of genome-edited rats by the rGONAD method.
Kobayashi T*, Namba M*, Koyano T*, Fukushima M, Sato M, Ohtsuka M, Matsuyama M. (*equal contribution)
BMC Biotechnol. 2018 Apr 2;18(1):19. doi: 10.1186/s12896-018-0430-5.
PubMed

 

i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases.
Ohtsuka M, Sato M, Miura H, Takabayashi S, Matsuyama M, Koyano T, Arifin N, Nakamura S, Wada K, Gurumurthy CB.
Genome Biol. (2018) Feb 26;19(1):25. doi: 10.1186/s13059-018-1400-x.
PubMed

 

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus.
Mii Y, Yamamoto T, Takada R, Mizumoto S, Matsuyama M, Yamada S, Takada S, Taira M.
Nat Commun. (2017) Dec 7;8(1):1973.
PubMed

 

Monoclonal Suncus Antibodies: Generation of Fusion Partners to Produce Suncus-Suncus Hybridomas.
Sado Y, Inoue S, Tomono Y, Matsuyama M, Fukushima M, Oohashi T, Jogahara T, Oda SI.
Acta Histochem Cytochem. (2017) Apr 27;50(2):71-84.
PubMed

 

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis.
Nakatsuka A, Matsuyama M, Yamaguchi S, Katayama A, Eguchi J, Murakami K, Teshigawara S, Ogawa D, Wada N, Yasunaka T, Ikeda F, Takaki A, Watanabe E, Wada J.
Sci Rep. (2016) Feb 17;6:21721. doi: 10.1038/srep21721.
PubMed