The fission yeast NDR kinase Orb6 and its signalling pathway MOR regulate cytoplasmic microtubule organization during the cell cycle

Kume K, Nishikawa K, Furuyama R, Fujimoto T, Koyano T, Matsuyama M, Mizunuma M, Hirata D.
Open Biol. 2024 Mar;14(3):230440. doi: 10.1098/rsob.230440. Epub 2024 Mar 6.
PubMed

 

Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast

Koyano T, Fujimoto T, Onishi K, Matsuyama M, Fukushima M, Kume K.
Genes Cells. 2023 Sep 18. doi: 10.1111/gtc.13069. Online ahead of print.
PubMed

 

ADAD2 functions in spermiogenesis and piRNA biogenesis in mice

Lu Y, Nagamori I, Kobayashi H, Kojima-Kita K, Shirane K, Chang HY, Nishimura T, Koyano T, Yu Z, Castañeda JM, Matsuyama M, Kuramochi-Miyagawa S, Matzuk MM, Ikawa M.
Andrology. 2023 Jan 25. doi: 10.1111/andr.13400. Online ahead of print.
PubMed

 

Mapping the protein binding site of the (pro)renin receptor using in silico 3D structural analysis

Ebihara A, Sugihara D, Matsuyama M, Suzuki-Nakagawa C, Nabi AHMN, Nakagawa T, Nishiyama A, Suzuki F.
Hypertens Res. 2022 Dec 9. doi: 10.1038/s41440-022-01094-w. Online ahead of print.
PubMed

 

Neuromedin U-deficient rats do not lose body weight or food intake

Yokogi K, Goto Y, Otsuka M, Ojima F, Kobayashi T, Tsuchiba Y, Takeuchi Y, Namba M, Kohno M, Tetsuka M, Takeuchi S, Matsuyama M*, Aizawa S*. (*equal contribution)
Sci Rep. 2022 Oct 27;12(1):17472. doi: 10.1038/s41598-022-21764-6.
PubMed

 

Retinal Cone Mosaic in sws1-Mutant Medaka (Oryzias latipes), A Teleost

Matsuo M, Matsuyama M, Kobayashi T, Kanda S, Ansai S, Kawakami T, Hosokawa E, Daido Y, Kusakabe TG, Naruse K, Fukamachi S.
Invest Ophthalmol Vis Sci. 2022 Oct 3;63(11):21. doi: 10.1167/iovs.63.11.21.
PubMed

 

Efficient genome editing in wild strains of mice using the i-GONAD method

Imai Y, Tanave A, Matsuyama M, Koide T.
Sci Rep. 2022 Aug 15;12(1):13821. doi: 10.1038/s41598-022-17776-x.
PubMed

 

Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network

Shimamura Y, Furuhashi K, Tanaka A, Karasawa M, Nozaki T, Komatsu S, Watanabe K, Shimizu A, Minatoguchi S, Matsuyama M, Sawa Y, Tsuboi N, Ishimoto T, Suzuki HI, Maruyama S.
Commun Biol. 2022 Jul 28;5(1):753. doi: 10.1038/s42003-022-03712-2.
PubMed

 

TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1

Akagi T, Hiramatsu-Asano S, Ikeda K, Hirano H, Tsuji S, Yahagi A, Iseki M, Matsuyama M, Mak TW, Nakano K, Ishihara K, Morita Y, Mukai T.
Front Immunol. 2022 Jul 22;13:926175. doi: 10.3389/fimmu.2022.926175. eCollection 2022.
PubMed

 

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

Oura S, Hino T, Satoh T, Noda T, Koyano T, Isotani A, Matsuyama M, Akira S, Ishiguro KI, Ikawa M.
PLoS Genet. 2022 Jun 1;18(6):e1010241. doi: 10.1371/journal.pgen.1010241. eCollection 2022 Jun.
PubMed

 

Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice.
Hiradate Y, Harima R, Yanai R, Hara K, Nagasawa K, Osada M, Kobayashi T, Matsuyama M, Kanno S, Yasui A, Tanemura K
Reprod Med Biol. 2022 Mar 30;21(1):e12452.doi: 10.1002/rmb2.12452. eCollection Jan-Dec 2022.
PubMed

 

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts

Minatoguchi S, Saito S, Furuhashi K, Sawa Y, Okazaki M, Shimamura Y, Kaihan AB, Hashimoto Y, Yasuda Y, Hara A, Mizutani Y, Ando R, Kato N, Ishimoto T, Tsuboi N, Esaki N, Matsuyama M, Shiraki Y, Kobayashi H, Asai N, Enomoto A, Maruyama S.
Sci Rep . 2022 Mar 30;12(1):5389. doi: 10.1038/s41598-022-09331-5.
PubMed

 

An improved iliac lymph node method for production of monoclonal antibodies.
Kobayashi T, Namba M, Kohno M, Koyano T, Sado Y, Matsuyama M.
Dev Growth Differ. 2022 Jan;64(1):38-47. doi: 10.1111/dgd.12766. Epub 2022 Jan 3.

PubMed

 

Creation of X-linked Alport syndrome rat model with Col4a5 deficiency.
Namba M, Kobayashi T, Kohno M, Koyano T, Hirose T, Fukushima M, Matsuyama M.
Sci Rep. 2021 Oct 21;11(1):20836. doi: 10.1038/s41598-021-00354-y.
PubMed

 

LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.
Zhang X, Sun J, Lu Y, Zhang J, Shimada K, Noda T, Zhao S, Koyano T, Matsuyama M, Zhou S, Wu J, Ikawa M, Liu M.
J Cell Sci. 2021 Oct 15;134(20):jcs259381. doi: 10.1242/jcs.259381. Epub 2021 Oct 21.
PubMed

 

GONAD: A new method for germline genome editing in mice and rats.
Namba M, Kobayashi T, Koyano T, Kohno M, Ohtsuka M, Matsuyama M.
Dev Growth Differ. 2021 Oct;63(8):439-447. doi: 10.1111/dgd.12746. Epub 2021 Oct 5.
PubMed

 

KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
Oura S, Koyano T, Kodera C, Horisawa-Takada Y, Matsuyama M, Ishiguro K, Ikawa M.
PLoS Genet. 2021 May 7;17(5):e1009412. doi:10.1371/journal.pgen.1009412. eCollection 2021 May.
PubMed

 

Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.
Yamakawa D, Katoh D, Kasahara K, Shiromizu T, Matsuyama M, Matsuda C, Maeno Y, Watanabe M, Nishimura Y, Inagaki M.
Cell Rep. 2021 Mar 9;34(10):108817. doi: 10.1016/j.celrep.2021.108817.
PubMed

 

Majority of alpha2,6-sialylated glycans in adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
Ohmi Y, Nishikaze T, Kitaura Y, Ito T, Yamamoto S, Sugiyama F, Matsuyama M, Takahashi Y, Takeda A, Kawahara T, Okajima T, Furukawa K, Furukawa K.
Glycobiology. 2020 Nov 25:cwaa105. doi: 10.1093/glycob/cwaa105.
PubMed

 

Antiproliferative Effects of Monoclonal Antibodies against (Pro)Renin Receptor in Pancreatic Ductal Adenocarcinoma.
Rahman A, Matsuyama M, Ebihara A, Shibayama Y, Hasan AU, Nakagami H, Suzuki F, Sun J, Kobayashi T, Hayashi H, Nakano D, Kobara H, Masaki T, Nishiyama A.
Mol Cancer Ther. 2020 Sep;19(9):1844-1855. doi: 10.1158/1535-7163.MCT-19-0228. Epub 2020 Jul 15.
PubMed

 

Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†.
Nozawa K, Zhang Q, Miyata H, Devlin DJ, Yu Z, Oura S, Koyano T, Matsuyama M, Ikawa M, Matzuk MM.
Biol Reprod. 2020 Aug 4;103(2):244-253. doi: 10.1093/biolre/ioaa040.
PubMed

 

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.
Noda T, Lu Y, Fujihara Y, Oura S, Koyano T, Kobayashi S, Matzuk MM, Ikawa M.
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502. doi: 10.1073/pnas.1922650117. Epub 2020 May 11.
PubMed

 

The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers.
Wang J, Nishiyama A, Matsuyama M, Wang Z, Yuan Y.
Cell Commun Signal. 2020 Mar 6;18(1):39. doi: 10.1186/s12964-020-0531-3.
PubMed

 

The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
Kumrungsee T, Kariya T, Hashimoto K, Koyano T, Yazawa N, Hashimoto T, Sanada Y, Matsuyama M, Sotomaru Y, Sakurai H, van de Loo FAJ, Yanaka N.
Sci Rep. 2019 Oct 1;9(1):14101. doi: 10.1038/s41598-019-50685-0.
PubMed

 

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis.
Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Takahashi M, Enomoto A.
Cancer Res. 2019 Aug 22. pii: canres.0454.2019. doi: 10.1158/0008-5472.
PubMed

 

The p21 dependent G2 arrest of the cell cycle in epithelial tubular cells links to the early stage of renal fibrosis.
Koyano T, Namba M, Kobayashi T, Nakakuni K, Nakano D, Fukushima M, Nishiyama A, Matsuyama M.
Sci Rep. 2019 Aug 19;9(1):12059. doi: 10.1038/s41598-019-48557-8.
PubMed

 

Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD.
Gurumurthy CB, Sato M, Nakamura A, Inui M, Kawano N, Islam MA, Ogiwara S, Takabayashi S, Matsuyama M, Nakagawa S, Miura H, Ohtsuka M.
Nat Protoc. 2019 Aug;14(8):2452-2482. doi: 10.1038/s41596-019-0187-x.
PubMed

 

Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain.
Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, Ihara Y, Misonou H, Miyasaka T.
J Neurosci. 2019 Aug 21;39(34):6781-6797.doi:10.1523/JNEUROSCI.2845-18.2019. Epub 2019 Jun 24.
PubMed

 

Distribution of endogenous normal tau in the mouse brain.
Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T.
J Comp Neurol. 2019 Apr 1;527(5):985-998. doi: 10.1002/cne.24577.
PubMed

 

Successful production of genome-edited rats by the rGONAD method.
Kobayashi T*, Namba M*, Koyano T*, Fukushima M, Sato M, Ohtsuka M, Matsuyama M. (*equal contribution)
BMC Biotechnol. 2018 Apr 2;18(1):19. doi: 10.1186/s12896-018-0430-5.
PubMed

 

i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases.
Ohtsuka M, Sato M, Miura H, Takabayashi S, Matsuyama M, Koyano T, Arifin N, Nakamura S, Wada K, Gurumurthy CB.
Genome Biol. 2018 Feb 26;19(1):25. doi: 10.1186/s13059-018-1400-x.
PubMed

 

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus.
Mii Y, Yamamoto T, Takada R, Mizumoto S, Matsuyama M, Yamada S, Takada S, Taira M.
Nat Commun. 2017 Dec 7;8(1):1973.
PubMed

 

Monoclonal Suncus Antibodies: Generation of Fusion Partners to Produce Suncus-Suncus Hybridomas.
Sado Y, Inoue S, Tomono Y, Matsuyama M, Fukushima M, Oohashi T, Jogahara T, Oda SI.
Acta Histochem Cytochem. 2017 Apr 27;50(2):71-84.
PubMed

 

Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis.
Nakatsuka A, Matsuyama M, Yamaguchi S, Katayama A, Eguchi J, Murakami K, Teshigawara S, Ogawa D, Wada N, Yasunaka T, Ikeda F, Takaki A, Watanabe E, Wada J.
Sci Rep. (2016) Feb 17;6:21721. doi: 10.1038/srep21721.
PubMed

 

Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice.
Tanaka H, Goto H, Inoko A, Makihara H, Enomoto A, Horimoto K, Matsuyama M, Kurita K, Izawa I, Inagaki M.
J Biol Chem. (2015) May 22;290(21):12984-12998. （巻頭表紙）
PubMed

 

Secreted Frizzled-related Protein 1 (Sfrp1) Regulates the Progression of Renal Fibrosis in a Mouse Model of Obstructive Nephropathy.
Matsuyama M, Nomori A, Nakakuni K, Shimono A, Fukushima M.
J Biol Chem. (2014) Nov 7;289(45):31526-33.
PubMed

 

Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells.
Matsuyama M, Tanaka H, Inoko A, Goto H, Yonemura S, Kobori K, Hayashi Y, Kondo E, Itohara S, Izawa I, Inagaki M.
J Biol Chem. (2013) Dec 13;288(50):35626-35.
This paper is selected as a 'Paper of the Week'.
This paper is selected as a 'Recommended' paper by Faculty of 1000.
PubMed

 

Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells.
Inoko A*, Matsuyama M*, Goto H, Ohmuro-Matsuyama Y, Hayashi Y, Enomoto M, Ibi M, Urano T, Yonemura S, Kiyono T, Izawa I, Inagaki M.(*equal contribution)
J Cell Biol. (2012) Apr 30;197(3):391-405.
This paper is selected as a 'Recommended' paper by Faculty of 1000.（巻頭表紙）
PubMed

 

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation.
Li P, Goto H, Kasahara K, Matsuyama M, Wang Z, Yatabe Y, Kiyono T, Inagaki M.
Mol Biol Cell. (2012) Apr;23(8):1582-92.
PubMed


The embryonic mouse gut tube as a model for analysis of epithelial polarity.
Matsuyama M, Shimono A.
Methods Mol Biol. (2012) 839:229-37.
PubMed

 

Nuclear Chk1 prevents premature mitotic entry.
Matsuyama M*, Goto H*, Kasahara K*, Kawakami Y, Nakanishi M, Kiyono T, Goshima N, Inagaki M. (*equal contribution)
J Cell Sci. (2011) Jul 1;124(Pt 13):2113-9.
PubMed

 

Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
Ibi M, Zou P, Inoko A, Shiromizu T, Matsuyama M, Hayashi Y, Enomoto M, Mori D, Hirotsune S, Kiyono T, Tsukita S, Goto H, Inagaki M.
J Cell Sci. (2011) Mar 15;124(Pt 6):857-64.
PubMed