分子細胞生物部門　　Division of Molecular Cell biology

Iron depletion is a novel therapeutic strategy to target cancer stem cells.
Ninomiya T, Ohara T, Noma K, Katsura Y, Katsube R, Kashima H, Kato T, Tomono Y, Tazawa H, Kagawa S, Shirakawa Y, Kimura F, Chen L, Kasai T, Seno M, Matsukawa A, Fujiwara T.
Oncotarget. 2017 Oct 12;8(58):98405-98416.
PubMed

The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets.
Morioka Y, Teshigawara K, Tomono Y, Wang D, Izushi Y, Wake H, Liu K, Takahashi HK, Mori S, Nishibori M.
J Pharmacol Sci. 2017 Aug;134(4):218-224.
PubMed

Monoclonal Suncus Antibodies: Generation of Fusion Partners to Produce Suncus-Suncus Hybridomas.
Sado Y, Inoue S, Tomono Y, Matsuyama M, Fukushima M, Oohashi T, Jogahara T, Oda SI.
Acta Histochem Cytochem. 2017 Apr 27;50(2):71-84.
PubMed

Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues.
Makihara H, Inaba H, Enomoto A, Tanaka H, Tomono Y, Ushida K, Goto M, Kurita K, Nishida Y, Kasahara K, Goto H, Inagaki M.
Biochem Biophys Res Commun. 2016 Sep 23; 478(3): 1323-9. doi: 10.1016/j.bbrc. 2016.08.122. Epub 2016 Aug 23.
PubMed

Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer.
Nishitani S, Noma K, Ohara T, Tomono Y, Watanabe S, Tazawa H, Shirakawa Y, Fujiwara T.
Int J Oncol. 2016 Oct;49(4):1351-9. doi: 10.3892/ijo.2016.3640. Epub 2016 Jul 29.
PubMed

Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma.
Uchida D, Takaki A, Ishikawa H, Tomono Y, Kato H, Tsutsumi K, Tamaki N, Maruyama T, Tomofuji T, Tsuzaki R, Yasunaka T, Koike K, Matsushita H, Ikeda F, Miyake Y, Shiraha H, Nouso K, Yoshida R, Umeda Y, Shinoura S, Yagi T, Fujiwara T, Morita M, Fukushima M, Yamamoto K, Okada H
Free Radic Res. 2016 Apr 25:1-12.
PubMed

Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) is induced by VEGF-A.
Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, Fukuda S, Sakaue T, Shirakata Y, Sayama K, Hashimoto K, Detmar M, Higashiyama S, Hirakawa S
J Biol Chem. 2016 Mar 10. pii: jbc.M115.683201.
PubMed

Iron depletion enhances the effect of sorafenib in hepatocarcinoma.
Urano S, Ohara T, Noma K, Katsube R, Ninomiya T, Tomono Y, Tazawa H, Kagawa S, Shirakawa Y, Kimura F, Nouso K, Matsukawa A, Yamamoto K, Fujiwara T
Cancer Biol Ther. 2016 Apr 18:0.
PubMed

Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer.
Hao H, Maeda Y, Fukazawa T, Yamatsuji T, Takaoka M, Bao XH, Matsuoka J, Okui T, Shimo T, Takigawa N, Tomono Y, Nakajima M, Fink-Baldauf IM, Nelson S, Seibel W, Papoian R, Whitsett JA, Naomoto Y.
PLoS One. 2013 Aug 16;8(8)
PubMed

A novel synergistic effect of iron depletion on antiangiogenic cancer therapy.
Ohara T, Noma K, Urano S, Watanabe S, Nishitani S, Tomono Y, Kimura F, Kagawa S, Shirakawa Y, Fujiwara T.
Int J Cancer. 2013 Jun 1;132(11):2705-13
PubMed

Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.
Nishikawa T, Takaoka M, Ohara T, Tomono Y, Hao H, Bao X, Fukazawa T, Wang Z, Sakurama K, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y.
Cancer Biol Ther. 2013 Mar;14(3):230-6.
PubMed

Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer.
Hao HF, Takaoka M, Bao XH, Wang ZG, Tomono Y, Sakurama K, Ohara T, Fukazawa T, Yamatsuji T, Fujiwara T, Naomoto Y.
Biochem Biophys Res Commun. 2012 Jul 13;423(4):744-9. Epub 2012 Jun 13.
PubMed

Gene expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1)in human osteoarthritic cartilage.
Terada C, Yoshida A, Nasu Y, Mori S, Tomono Y, Tanaka M, Takahashi HK, Nishibori M, Ozaki T, Nishida K.
Acta Med Okayama. 2011 Dec;65(6):369-77.
PubMed

Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non-small-cell lung cancer cells.
Ohara T, Takaoka M, Toyooka S, Tomono Y, Nishikawa T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y.
Cancer Sci. 2011 Jul;102(7):1344-9. doi: 10.1111/j.1349-7006.2011.01967.x. Epub 2011 Jun 2.
PubMed

Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium.
Motoki T, Naomoto Y, Hoshiba J, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M, Tomono Y, Fujiwara Y, Tsuchita H, Gunduz M, Nagatsuka H, Tanaka N, Fujiwara T.
World J Gastroenterol. 2011 Feb 14;17(6):717-26.
PubMed